Spicy Cajun Chicken Alfredo

Featured in: Easy Weeknight Meals

This dish features tender chicken breasts seasoned with vibrant Cajun spices, seared to golden perfection and served atop fettuccine noodles. The pasta is enveloped in a luscious Alfredo sauce, crafted from butter, garlic, heavy cream, smoked paprika, and Parmesan cheese, delivering a creamy texture and subtle smoky heat. A touch of chili flakes enhances the warmth, while fresh parsley adds brightness. Ideal for those seeking a flavorful, satisfying meal with a harmonious blend of spice and creaminess.

Updated on Sat, 15 Nov 2025 16:56:00 GMT
Creamy plate of Spicy Cajun Chicken Alfredo with vibrant parsley garnish for a perfect meal. Save
Creamy plate of Spicy Cajun Chicken Alfredo with vibrant parsley garnish for a perfect meal. | ovenharmony.com

A bold, creamy pasta dish featuring tender Cajun-spiced chicken tossed with fettuccine in a rich Alfredo sauce, perfect for spice lovers.

Making Spicy Cajun Chicken Alfredo at home was a game-changer for dinner nights. The chicken gets wonderfully caramelized and the sauce perfectly coats every pasta strand.

Ingredients

  • Boneless, skinless chicken breasts: 2 large
  • Cajun seasoning: 2 tablespoons
  • Olive oil: 1 tablespoon
  • Fettuccine: 340 g (12 oz)
  • Unsalted butter: 2 tablespoons
  • Garlic (minced): 3 cloves
  • Heavy cream: 1 cup (240 ml)
  • Freshly grated Parmesan cheese: 1 cup (100 g)
  • Smoked paprika: 1/2 teaspoon
  • Chili flakes (optional): 1/2 teaspoon
  • Salt and black pepper: To taste
  • Chopped fresh parsley: 2 tablespoons
  • Extra grated Parmesan cheese: For garnish

Instructions

Cook the pasta:
Cook the fettuccine according to package instructions in salted boiling water until al dente. Reserve 1/2 cup pasta water, then drain and set aside.
Prepare the chicken:
Pat chicken breasts dry and coat them evenly with Cajun seasoning.
Cook the chicken:
Heat olive oil in a large skillet over medium-high heat. Add chicken and cook 5 6 minutes per side, or until fully cooked and golden brown. Remove and let rest for 5 minutes, then slice thinly.
Make Alfredo sauce:
In the same skillet, reduce heat to medium and add butter. Sauté minced garlic for 1 minute until fragrant.
Finish the sauce:
Stir in heavy cream, smoked paprika, and chili flakes. Bring to a gentle simmer, then whisk in Parmesan cheese until melted and smooth. Season with salt and pepper.
Combine pasta and sauce:
Add cooked fettuccine to the sauce, tossing to coat. Add reserved pasta water a little at a time as needed for a silky sauce.
Serve:
Top pasta with sliced Cajun chicken, garnish with parsley and extra Parmesan. Serve immediately.
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This recipe is always a hit at family gatherings. Everyone loves the spicy kick and creamy sauce, making it an instant favorite for both kids and adults.

Required Tools

Large pot, large skillet, tongs, chefs knife, cutting board, measuring cups and spoons are essential for preparation.

Allergen Information

Contains dairy and gluten. Cajun seasoning may have common allergens. Always verify ingredient labels for possible cross-contamination.

Nutritional Information

Each serving provides about 610 calories, 27 g total fat, 54 g carbohydrates, and 38 g protein.

Sizzling, golden-brown chicken tops a plate of Spicy Cajun Chicken Alfredo, ready to serve with extra cheese. Save
Sizzling, golden-brown chicken tops a plate of Spicy Cajun Chicken Alfredo, ready to serve with extra cheese. | ovenharmony.com

Enjoy this spicy Cajun chicken Alfredo with a crisp white wine for the perfect balance. Savor the bold flavors and creamy texture in every bite.

Recipe FAQ

What is the best way to cook the chicken?

Season chicken breasts evenly with Cajun spices and sear in olive oil over medium-high heat until golden and cooked through, about 5-6 minutes per side.

Can I substitute the pasta type?

Yes, penne or linguine can be used instead of fettuccine for a different texture and presentation.

How do I adjust the spiciness level?

Increase the amount of Cajun seasoning or add more chili flakes to enhance the heat according to your preference.

What can I use instead of heavy cream for the sauce?

Using half-and-half will create a lighter sauce while maintaining creamy consistency, perfect for a less rich outcome.

How to achieve a silky sauce consistency?

Reserve some pasta water when cooking noodles and add it gradually to the sauce to adjust its thickness and silkiness.

Spicy Cajun Chicken Alfredo

Tender Cajun-spiced chicken combined with fettuccine in a rich creamy sauce, bursting with bold flavors and mild heat.

Prep duration
15 min
Cook duration
25 min
Complete duration
40 min
Created by Claire Johnson

Classification Easy Weeknight Meals

Complexity Medium

Heritage American

Output 4 Portions

Dietary considerations None specified

Components

Chicken

01 2 large boneless, skinless chicken breasts
02 2 tablespoons Cajun seasoning
03 1 tablespoon olive oil

Pasta

01 12 ounces fettuccine

Alfredo Sauce

01 2 tablespoons unsalted butter
02 3 cloves garlic, minced
03 1 cup heavy cream
04 1 cup freshly grated Parmesan cheese (about 100 grams)
05 1/2 teaspoon smoked paprika
06 1/2 teaspoon chili flakes (optional)
07 Salt, to taste
08 Black pepper, to taste

Garnishes

01 2 tablespoons chopped fresh parsley
02 Extra grated Parmesan cheese

Directions

Phase 01

Cook Fettuccine: Boil salted water and cook fettuccine according to package instructions until al dente. Reserve 1/2 cup pasta cooking water, then drain and set aside.

Phase 02

Prepare Chicken: Pat chicken breasts dry and coat evenly with Cajun seasoning.

Phase 03

Cook Chicken: Heat olive oil over medium-high heat in a large skillet. Sear chicken for 5 to 6 minutes per side until cooked through and golden brown. Remove from skillet and let rest for 5 minutes, then slice thinly.

Phase 04

Sauté Garlic: Reduce heat to medium, add butter to the skillet, and sauté minced garlic for 1 minute until fragrant.

Phase 05

Make Alfredo Sauce: Stir in heavy cream, smoked paprika, and chili flakes. Simmer gently, then whisk in Parmesan cheese until the sauce is smooth. Season with salt and black pepper to taste.

Phase 06

Combine Pasta and Sauce: Add cooked fettuccine to the sauce, tossing to coat evenly. Gradually add reserved pasta water if needed to achieve desired sauce consistency.

Phase 07

Finish and Serve: Top pasta with sliced Cajun chicken. Garnish with chopped parsley and extra Parmesan cheese. Serve immediately.

Necessary tools

  • Large pot
  • Large skillet
  • Tongs
  • Chef's knife
  • Cutting board
  • Measuring cups and spoons

Allergy details

Review each component for potential allergens and consult healthcare professionals if you're unsure about ingredients.
  • Contains dairy from cream, butter, and Parmesan cheese
  • Contains gluten in pasta
  • Cajun seasoning may include mustard or celery allergens

Nutritional information (each portion)

These values are approximate guidelines only and shouldn't replace professional medical guidance.
  • Energy: 610
  • Fats: 27 g
  • Carbohydrates: 54 g
  • Proteins: 38 g